Multiple leisons in 70%
99.7%. Cervical ca related to HPV
HPV double DNA
Early gene E   late gene L. Vaccine L1 gene
HPV vaccine  16 18 responsible 70% Ca cervix 
Quadrivalent vaccine Gardasil 6 11 16 18
9-26 yrs
Cervarix 
How long does immunization work?
Should men be vaccinated?
 
>120 types HPV
E6/E7 gene 
Smoking cessation engouages regression of CIN
Barrier methods regression of CIN
circumcision ?
Recall system reduction in incidence 60%
  
 
 
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